Phentermine and Sibutramine are two weight loss drugs, prescribed as a supplement to a diet therapy and regular physical exertion. The only difference is that Phentermine is meant for a short-term use, 12 weeks maximum. While Sibutramine can be used for weight loss within a year.
Both these weight loss drugs are prescribed for management of exogenous obesity in patients with BMI of or more than 30, as well as those, whose BMI is above 27 but accompanied by other risk factors (in particular: hypertension, diabetes mellitus and hyperlipidemia).
The FDA approved Phentermine drug for the treatment of obesity in 1959. Today, Phentermine is accessible under many trade names on global pharmaceutical market.
The best-known Phentermine generics are: Ionamin, Metermine, Adipex and Duromine.
- Sibutramine under the trade name Meridia was approved by the FDA in 1997. Over time, it was established that Sibutramine intake increases the risk of strokes and other cardiovascular diseases.
Therefore, Sibutramine was discontinued on the markets of the USA, EU, UK, Canada and Australia.
- Phentermine and Sibutramine help to lose weight by suppressing appetite.
- Phentermine belongs to the drug class of amphetamines.
- Phentermine effect is manifested by acting on norepinephrine neurotransmitter in the brain, which is responsible for satiety.
- Sibutramine s a serotonin-norepinephrine reuptake inhibitor (SNRIs).
Although therapeutic action of Sibutramine is associated with amphetamine, its mechanism of action is different from Phentermine.
Unlike Phentermine, which inhibits the release of neurotransmitters, Sibutramine acts on the reuptake of neurotransmitters. Thus, Sibutramine reduces the reuptake of dopamine by 16%, serotonin by 53% and norepinephrine by 54%.
Weight loss drugs Phentermine and Sibutramine have almost equal contraindications and side effects. For instance, Phentermine and Sibutramine have equal age restrictions. Both drugs (Phentermine and Sibutramine) are contraindicated for use to patients under 18 and over 65 years old.
Side effects, occurring during the use of Phentermine, are mild and pass without special measures in several days.
There are most common side effects, such as:
The most observed Sibutramine side effects are: dry mouth, headache, nausea and violation of defecation. In case patient has such Sibutramine side effects as very high blood pressure and arrhythmia, he should stop taking Sibutramine weight loss drug and consult a specialist.
In order to buy Phentermine and Sibutramine online, you don’t have to fill out medical questionnaire. Thus, you can order Sibutramine and Phentermine with no prescription in just 3-5 minutes.