Sibutramine drug interactions

Administration of weight loss drug Sibutramine in combination with other drugs can cause the development of side effects. Therefore, prior to initiating the drug therapy you should study the information about drug interactions of Sibutramine.

  • Inhibitors of various cytochrome P450 isozymes (Ketoconazole, Erythromycin, Cimetidine) may increase the plasma concentration of Sibutramine. Therefore, for obese people taking inhibitors of the Cytochrome P450 may be required to reduce the daily dose of Sibutramine.
  • Sibutramine may potentiate the effect of SSRIs (Paroxetine, Sertraline, Sumatriptan) on the serotonergic system. Strengthening of serotonergic activity promotes the development of serotonin syndrome, which may cause the following symptoms sweating, heart rate, nausea, flatulence, strong emotional arousal. In order to prevent the emergence of serotonin syndrome, Sibutramine should not be taken in the combination with SSRIs.
  • The serotonin syndrome may develop and in the case if Sibutramine is taken in the combination with MAO inhibitors, agonists of 5-HT1-receptors, derivatives of ergot alkaloids, opioids, antitussive drugs with the central mode of action. The interval between the Sibutramine use and drugs include in the listed groups must be at least two weeks.
  • During simultaneous administration of Sibutramine with drugs of the benzodiazepines class (including Lorazepam), some people may experience CNS side effects (dizziness, drowsiness, impaired concentration).
  • Due to weight loss, blood lipid level can decrease and lipid profile is improved in obese people. If before the start of obesity drug therapy the obese patient was taking a lipid-lowering drug (including statins Simvastatin, Atorvastatin), after significant weight loss and improvement in lipid profile, it may be necessary to adjust the daily doses of statins and other lipid-lowering drugs.
  • Sibutramine is contraindicated in the combination with Ephedrine and Pseudoephedrine. These amphetamines may increase the influence of Sibutramine on the cardiovascular system and contribute to the excessive increase in blood pressure and heart rate.
  • Sibutramine may adversely affect the pharmacological activity of anticoagulants (e.g., Warfarin). Therefore, diet pills Sibutramine are not recommended for including the anticoagulant therapy.
  • The clinical studies have demonstrated that Sibutramine does not affect the efficacy and safety of oral contraceptives. Therefore, obese women can use diet pills Sibutramine in the combination with contraceptives.

This is not a complete list of drug interactions of weight loss drug Sibutramine. Ask your physician for more detailed information about the interactions of Sibutramine with other drugs.

If you have never taken Sibutramine and want to order this anti-obesity drug online without a prescription, please ask the pharmacist of the online pharmacy your questions.

You can buy Sibutramine online and get an expert advice from a pharmacist anywhere in the world.

One Comment

  1. Nina August 21, 2014 at 9:29 am

    Too many dangerous (for me) side effects

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